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| *Dopamine level is associated with playfulness. Increased dopamine levels are linked to increased playfulness. | | *Dopamine level is associated with playfulness. Increased dopamine levels are linked to increased playfulness. |
| *Dopaminergic neurons are concentrated in the mesocorticolimbic dopamine system of the midbrain. This is thought to be part of the reward system that somehow assigns value to adaptive behaviours. Recent experiments have shown that normal dogs treated with the drug improve their performance in certain learned tasks and it is believed that this is due to improved function of the reward system. | | *Dopaminergic neurons are concentrated in the mesocorticolimbic dopamine system of the midbrain. This is thought to be part of the reward system that somehow assigns value to adaptive behaviours. Recent experiments have shown that normal dogs treated with the drug improve their performance in certain learned tasks and it is believed that this is due to improved function of the reward system. |
− | ????In the Miller model this could raise the height and perhaps increase the gradient of the approach line, whilst also lowering the avoidance line????
| + | <font color="red">??In the Miller model this could raise the height and perhaps increase the gradient of the approach line, whilst also lowering the avoidance line??</font> |
| *D<sub>1</sub> receptors are affected in mood disorders and stereotypes and manifest their post-synaptic inhibition in the limbic system. In mood disorders and stereotypies D<sub>2</sub>, D<sub>3</sub> and D<sub>4</sub> receptors are all also affected. | | *D<sub>1</sub> receptors are affected in mood disorders and stereotypes and manifest their post-synaptic inhibition in the limbic system. In mood disorders and stereotypies D<sub>2</sub>, D<sub>3</sub> and D<sub>4</sub> receptors are all also affected. |
| *Dopamine is also important in the putative ‘seeking’ circuit, which is involved in reinforcement of search, exploratory and investigatory behaviours. Animals that have an enhancement of the ‘seeking’ system become immensely interested in what is around them and become excited when they anticipate the arrival of things that they want. | | *Dopamine is also important in the putative ‘seeking’ circuit, which is involved in reinforcement of search, exploratory and investigatory behaviours. Animals that have an enhancement of the ‘seeking’ system become immensely interested in what is around them and become excited when they anticipate the arrival of things that they want. |
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| :*Cognitive decline [hypothetically of DAT]. | | :*Cognitive decline [hypothetically of DAT]. |
| *Unlicensed | | *Unlicensed |
− | :*Other fear related problems [including aggression] - have also read that can cause an increase in aggression? - does this depend on the cause of aggression as to whether appropriate? | + | :*Other fear related problems [including aggression] <font color="red">- have also read that can cause an increase in aggression? - does this depend on the cause of aggression as to whether appropriate?</font> |
| :*Spraying [fear related in cats] | | :*Spraying [fear related in cats] |
| :*Hyperactivity | | :*Hyperactivity |