Changes

==Mechanism of Action==

==Mechanism of Action==

Selegiline is a selective monoamine oxidase (MAO) type B inhibitor (I), also commonly known as L-deprenyl. Monoamine Oxidase (MAO) is the main enzyme responsible for breakdown of the monoamine neurotransmitters (adrenaline, nor-adrenaline, serotonin, histamine and dopamine). Selegiline has a high specificity for dopamine. MAO-Is function by preventing oxidative deamination of brain amines, augmenting levels of these substances<ref>Overall, K.L., 2001. Pharmacological Treatment in Behavioural Medicine: The Importance of Neurochemistry, Molecular Biology and Mechanistic Hypotheses. The Veterinary Journal, 162, 9-23</ref>.

Selegiline is a selective monoamine oxidase (MAO) type B inhibitor (I), also commonly known as L-deprenyl. Monoamine Oxidase (MAO) is the main enzyme responsible for breakdown of the monoamine neurotransmitters (adrenaline, nor-adrenaline, serotonin, histamine and dopamine). Selegiline has a high specificity for dopamine. MAO-Is function by preventing oxidative deamination of brain amines, augmenting levels of these substances<ref name="Overall">Overall, K.L., 2001. Pharmacological Treatment in Behavioural Medicine: The Importance of Neurochemistry, Molecular Biology and Mechanistic Hypotheses. The Veterinary Journal, 162, 9-23</ref>.

Two forms exist, these are different in terms of their distribution in tissues and substrate specificity:

Two forms exist, these are different in terms of their distribution in tissues and substrate specificity:

*Amitraz: found in some tick collars

*Amitraz: found in some tick collars

A minimum of a 2 week gap should be allowed between withdrawal of selegiline and initiation of treatment with a tricyclic antidepressant or selective serotonin reuptake inhibitor. Due to the long half-life of fluoxetine and its active metabolites, at least 5 weeks should elapse between discontinuation of fluoxetine and initiation of treatment with selegiline.

A minimum of a 2 week gap should be allowed between withdrawal of selegiline and initiation of treatment with a tricyclic antidepressant or selective serotonin reuptake inhibitor<ref name="Overall">. Due to the long half-life of fluoxetine and its active metabolites, at least 5 weeks should elapse between discontinuation of fluoxetine and initiation of treatment with selegiline.

Note that most of the potential interactions relate to mixed and selective MAOA inhibitors in man, but it is sensible to be aware of these interactions when using a drug, like selegiline, that has a short history of use in veterinary medicine. Any adverse reaction should be reported via the NOAH reporting system.

Note that most of the potential interactions relate to mixed and selective MAOA inhibitors in man, but it is sensible to be aware of these interactions when using a drug, like selegiline, that has a short history of use in veterinary medicine. Any adverse reaction should be reported via the NOAH reporting system.