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==Adverse Effects<ref>Wiersma, J., Honig, A. & Peters, F. P. J. (2000). Clomipramine-induced allergic hepatitis: a case report. International Journal of Psychiatry in Clinical Practice 4, 69–71.</ref>==
 
==Adverse Effects<ref>Wiersma, J., Honig, A. & Peters, F. P. J. (2000). Clomipramine-induced allergic hepatitis: a case report. International Journal of Psychiatry in Clinical Practice 4, 69–71.</ref>==
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===Comparison of Effects and Adverse Effects for Clomipramine and Related Drugs===
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{| class="wikitable"
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|-
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! Drug !! Class !! 5-HT:NorAdrenaline Blocking ratio !! H<sub>1</sub> Blockade !! Ach (Muscarinic) Blockade
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|-
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| Amitriptyline || TCA || 1:4 || +++ || +++
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|-
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| Clomipramine || TCA || 5:1 || ++ || ++
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|-
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| Fluoxetine || SSRI || 15:1 ||  || +
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|-
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| Fluvoxamine || SSRI || 150:1 ||  || +
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|-
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| Sertraline || SSRI || 150:1 ||  || +
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|}
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The blocking ratio indicates the relative effect of the agent on reuptake of 5-HT vs. noradrenaline. Fluoxetine is 3 times more selective for 5-HT than clomipramine. Clomipramine was the first TCA whose ratio favours 5-HT reuptake inhibition, and hence its title of non-selective serotonin reuptake inhibitor (SRI).
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{| class="wikitable"
 
{| class="wikitable"
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