694
edits
Changes
→Adverse EffectsWiersma, J., Honig, A. & Peters, F. P. J. (2000). Clomipramine-induced allergic hepatitis: a case report. International Journal of Psychiatry in Clinical Practice 4, 69–71.
==Adverse Effects<ref>Wiersma, J., Honig, A. & Peters, F. P. J. (2000). Clomipramine-induced allergic hepatitis: a case report. International Journal of Psychiatry in Clinical Practice 4, 69–71.</ref>==
==Adverse Effects<ref>Wiersma, J., Honig, A. & Peters, F. P. J. (2000). Clomipramine-induced allergic hepatitis: a case report. International Journal of Psychiatry in Clinical Practice 4, 69–71.</ref>==
===Comparison of Effects and Adverse Effects for Clomipramine and Related Drugs===
{| class="wikitable"
|-
! Drug !! Class !! 5-HT:NorAdrenaline Blocking ratio !! H<sub>1</sub> Blockade !! Ach (Muscarinic) Blockade
|-
| Amitriptyline || TCA || 1:4 || +++ || +++
|-
| Clomipramine || TCA || 5:1 || ++ || ++
|-
| Fluoxetine || SSRI || 15:1 || || +
|-
| Fluvoxamine || SSRI || 150:1 || || +
|-
| Sertraline || SSRI || 150:1 || || +
|}
The blocking ratio indicates the relative effect of the agent on reuptake of 5-HT vs. noradrenaline. Fluoxetine is 3 times more selective for 5-HT than clomipramine. Clomipramine was the first TCA whose ratio favours 5-HT reuptake inhibition, and hence its title of non-selective serotonin reuptake inhibitor (SRI).
{| class="wikitable"
{| class="wikitable"