| Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) which functions by inhibiting the reuptake of serotonin in the pre-synaptic neuron. This inhibition of uptake of reuptake of 5-HT<sub>1A</sub> into pre-synaptic neurons is highly selective and does not affect noradrenaline, dopamine, acetylcholine, histaminic or alpha-1 adrenergic receptors. 5-HT<sub>1A</sub> receptors have an effect on mood and behaviour. SSRIs are derived from TCAs, such as [[Clomipramine]]. SSRIs act to bring about changes in conformation of receptors, this can take 3-5 weeks<ref>Overall, K.L., 2004. Paradigms for pharmacologic use as a treatment component in feline behavioural medicine. Journal of Feline Medicine and Surgery 6, 29–42</ref>. Regulation of second messengers (cAMP, Ca<sup>2+</sup>, cGMP, IP<sub>3</sub>) is responsible for the major effect. Their actions on protein kinases then act to change neuronal metabolism and receptor protein transcription<ref>Overall, K.L., 2001. Pharmacological Treatment in Behavioural Medicine: The Importance of Neurochemistry, Molecular Biology and Mechanistic Hypotheses. The Veterinary Journal, 162, 9–23</ref>. | | Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) which functions by inhibiting the reuptake of serotonin in the pre-synaptic neuron. This inhibition of uptake of reuptake of 5-HT<sub>1A</sub> into pre-synaptic neurons is highly selective and does not affect noradrenaline, dopamine, acetylcholine, histaminic or alpha-1 adrenergic receptors. 5-HT<sub>1A</sub> receptors have an effect on mood and behaviour. SSRIs are derived from TCAs, such as [[Clomipramine]]. SSRIs act to bring about changes in conformation of receptors, this can take 3-5 weeks<ref>Overall, K.L., 2004. Paradigms for pharmacologic use as a treatment component in feline behavioural medicine. Journal of Feline Medicine and Surgery 6, 29–42</ref>. Regulation of second messengers (cAMP, Ca<sup>2+</sup>, cGMP, IP<sub>3</sub>) is responsible for the major effect. Their actions on protein kinases then act to change neuronal metabolism and receptor protein transcription<ref>Overall, K.L., 2001. Pharmacological Treatment in Behavioural Medicine: The Importance of Neurochemistry, Molecular Biology and Mechanistic Hypotheses. The Veterinary Journal, 162, 9–23</ref>. |
| :*Treatment of canine separation anxiety<ref>Landsberg, G.M., Melese, P., Sherman, B.L., Neilson, J.C., Zimmerman, A., Clarke, T.P., 2008. Effectiveness of fluoxetine chewable tablets in the treatment of canine separation anxiety. Journal of Veterinary Behavior 3, 12-19</ref><ref>Dodman, N.H., Shuster, L., 1994. Pharmacologic approaches to managing behaviour problems in small animals. Vet. Med. 89, 960-969.</ref><ref>Beaver, B.V., 1999. Canine Behavior: A Guide for Veterinarians. W.B. Saunders Company, Philadelphia, PA, pp. 26-28.</ref><ref>Overall, K.L., 2001. Pharmacological treatment in behavioral medicine: the importance of neurochemistry, molecular biology and mechanistic hypotheses. Vet. J. 162, 9-23.</ref><ref>Landsberg, G., Hunthausen, W., Ackerman, L., 2003. In: Handbook of Behavior Problems of the Dog and Cat, 2nd ed. Elsevier Saunders, Philadelphia, pp. 258-267.</ref><ref>Simpson, B.S., Papich, M.G., 2003. Pharmacologic management in veterinary behavioral medicine. Vet. Clin. North Am.: Small Anim. Pract. 33, 365-404.</ref><ref name="Simpson">Simpson, B.S., Landsberg, G.M., Reisner, I.R., Ciribassi, J.J., Horwitz, D., Houpt, K.A., Kroll, T.L., Luescher, A., Moffat, K.S., Douglass, G., Robertson-Plouch, C., Veenhuizen, M.F., Zimmerman, A., Clark, T.P., 2007. Effects of Reconcile (fluoxetine) chewable tablets plus behavior management for canine separation anxiety. Vet. Ther. 8, 18-31. Sonawalla, S.</ref> in conjunction with behaviour modification in dogs over 6 months old. | | :*Treatment of canine separation anxiety<ref>Landsberg, G.M., Melese, P., Sherman, B.L., Neilson, J.C., Zimmerman, A., Clarke, T.P., 2008. Effectiveness of fluoxetine chewable tablets in the treatment of canine separation anxiety. Journal of Veterinary Behavior 3, 12-19</ref><ref>Dodman, N.H., Shuster, L., 1994. Pharmacologic approaches to managing behaviour problems in small animals. Vet. Med. 89, 960-969.</ref><ref>Beaver, B.V., 1999. Canine Behavior: A Guide for Veterinarians. W.B. Saunders Company, Philadelphia, PA, pp. 26-28.</ref><ref>Overall, K.L., 2001. Pharmacological treatment in behavioral medicine: the importance of neurochemistry, molecular biology and mechanistic hypotheses. Vet. J. 162, 9-23.</ref><ref>Landsberg, G., Hunthausen, W., Ackerman, L., 2003. In: Handbook of Behavior Problems of the Dog and Cat, 2nd ed. Elsevier Saunders, Philadelphia, pp. 258-267.</ref><ref>Simpson, B.S., Papich, M.G., 2003. Pharmacologic management in veterinary behavioral medicine. Vet. Clin. North Am.: Small Anim. Pract. 33, 365-404.</ref><ref name="Simpson">Simpson, B.S., Landsberg, G.M., Reisner, I.R., Ciribassi, J.J., Horwitz, D., Houpt, K.A., Kroll, T.L., Luescher, A., Moffat, K.S., Douglass, G., Robertson-Plouch, C., Veenhuizen, M.F., Zimmerman, A., Clark, T.P., 2007. Effects of Reconcile (fluoxetine) chewable tablets plus behavior management for canine separation anxiety. Vet. Ther. 8, 18-31. Sonawalla, S.</ref> in conjunction with behaviour modification in dogs over 6 months old. |