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Selective Serotonin Reuptake Inhibitors (Clomipramine, Fluoxetine) (view source)

Revision as of 12:41, 12 September 2014

918 bytes removed , 12:41, 12 September 2014

→‎Effects on Anxiety and Panic

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Any adverse reaction should be reported via the NOAH reporting system.

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~~==Effects on Anxiety and Panic==~~

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Panic is a specific manifestation of anxiety and the mechanism of action of drugs that reduce panic share a common factor. Only drugs that reduce the firing rate of neurons in the Locus Coeruleus (LC) effectively reduce panic.

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Numerous models of anxiety have been tested in animals. Many are not apparently reliable detectors of anxiolytic effect, and have not been applied to more modern anxiolytic/antidepressant drugs like SSRIs/SRIs. Those in which there is a response to TCA/SRI and SSRI drugs include:

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*Approach-avoidance conflict (Stretched approach posture test).

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*Separation distress vocalisation (guinea pig isolation calls, rat pup isolation ultrasonic vocalisation).

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*Defensive burying in rodents (only some 5-HT reuptake inhibitors)

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~~Interestingly no effect has been found in those tests (so far performed) that involve conditioned fear potentiated startle responses.~~

==Use==

Jon Bowen

694

edits