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Selective Serotonin Reuptake Inhibitors (Clomipramine, Fluoxetine) (view source)
Revision as of 13:16, 12 September 2014
, 13:16, 12 September 2014→Adverse EffectsWiersma, J., Honig, A. & Peters, F. P. J. (2000). Clomipramine-induced allergic hepatitis: a case report. International Journal of Psychiatry in Clinical Practice 4, 69–71.
The blocking ratio indicates the relative effect of the agent on reuptake of serotonin vs. noradrenaline. Fluoxetine is 3 times more selective for serotonin than clomipramine. Clomipramine was the first TCA whose ratio favours serotonin reuptake inhibition, and hence its title of non-selective serotonin reuptake inhibitor (SRI). The level of anticholinergic effect is usually also decreased with increasing serotonergic selectivity.
The blocking ratio indicates the relative effect of the agent on reuptake of serotonin vs. noradrenaline. Fluoxetine is 3 times more selective for serotonin than clomipramine. Clomipramine was the first TCA whose ratio favours serotonin reuptake inhibition, and hence its title of non-selective serotonin reuptake inhibitor (SRI). The level of anticholinergic effect is usually also decreased with increasing serotonergic selectivity.
===Medical cautions===
'''Caution should be taken if the animal suffers from any of the following pre-existing medical conditions:'''
'''Caution should be taken if the animal suffers from any of the following pre-existing medical conditions:'''
*Heart disease, especially heart block and arrythmias <ref>Pouchelon, J. L., Martel, E., Champeroux, P., Richard, S. & King, J. N. (2000). Effect of clomipramine hydrochloride on the electrocardiogram and heart rate of dogs. American Journal of Veterinary Research, in press.</ref><ref>Reich, M. R., Ohad, D. G., Overall, K. L. & Dunham, A. E. (2000). Electrocardiographic assessment of antianxiety medication in dogs and correlation with drug serum concentration. Journal of the American Veterinary Medical Association 216, 1571–5.</ref>
*Heart disease, especially heart block and arrythmias <ref>Pouchelon, J. L., Martel, E., Champeroux, P., Richard, S. & King, J. N. (2000). Effect of clomipramine hydrochloride on the electrocardiogram and heart rate of dogs. American Journal of Veterinary Research, in press.</ref><ref>Reich, M. R., Ohad, D. G., Overall, K. L. & Dunham, A. E. (2000). Electrocardiographic assessment of antianxiety medication in dogs and correlation with drug serum concentration. Journal of the American Veterinary Medical Association 216, 1571–5.</ref>