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==Prognosis==
 
==Prognosis==
The prognosis for cats with indoor spray marking appears to be enhanced by the use of drug (fluoxetine, clomipramine) and pheromone (F3 fraction of facial mark, Feliway®), with these treatments significantly increasing the probability of a cessation or 90% reduction in spraying. In a meta-analysis of treatment effect, fluoxetine appeared to be the most effective medication, but sample sizes in both of the included studies was small. Studies suggest that a period of 8-16 weeks is required to establish efficacy of either of these drugs. Feliway produced no significant increase in the proportion of cats showing a cessation or 90% reduction in spray marking in less than 4 weeks, but improvements were significant for treatment durations of more than 4 weeks. This suggests that a combination of pheromone and pharmaceutical interventions, with environmental modifications, is most likely to produce a rapid response and good outcome.
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The prognosis for cats with indoor spray marking appears to be enhanced by the use of drug (fluoxetine, clomipramine) and pheromone (F3 fraction of facial mark, Feliway®), with these treatments significantly increasing the probability of a cessation or 90% reduction in spraying (Mills 3). In a meta-analysis of treatment effect, fluoxetine appeared to be the most effective medication, but sample sizes in both of the included studies was small. Studies suggest that a period of 8-16 weeks is required to establish efficacy of either of these drugs. Feliway produced no significant increase in the proportion of cats showing a cessation or 90% reduction in spray marking in less than 4 weeks, but improvements were significant for treatment durations of more than 4 weeks(Mills 3). This suggests that a combination of pheromone and pharmaceutical interventions, with environmental modifications, is most likely to produce a rapid response and good outcome.
 
   
 
   
 
However, cats with a history of indoor marking are likely to relapse at some point in the future, because this behaviour is normal and situations outside the owner’s control may create the conditions for a new bout of marking. Typical times when marking may re-emerge are after major home redecoration or reorganisation, after a house move, or the introduction of a new stressor (new baby, new pet). Spring and summer are times when cats seek to re-establish territorial boundaries, and are therefore a time when there is an increased risk of conflict and stress between cats.
 
However, cats with a history of indoor marking are likely to relapse at some point in the future, because this behaviour is normal and situations outside the owner’s control may create the conditions for a new bout of marking. Typical times when marking may re-emerge are after major home redecoration or reorganisation, after a house move, or the introduction of a new stressor (new baby, new pet). Spring and summer are times when cats seek to re-establish territorial boundaries, and are therefore a time when there is an increased risk of conflict and stress between cats.
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