Changes

With absolute erythrocytosis, serum EPO determinations have been recommended to differentiate primary from secondary causes. Unfortunately, considerable overlap exists in EPO activity among normal animals, animals with primary erythrocytosis, and animals with secondary erythrocytosis. Furthermore, current availability of validated EPO assays for companion animals is limited. Routine examination of bone marrow is not useful to distinguish primary from secondary erythrocytosis because both conditions show erythroid hyperplasia. As a result, primary erythrocytosis usually is diagnosed by eliminating secondary causes.

With absolute erythrocytosis, serum EPO determinations have been recommended to differentiate primary from secondary causes. Unfortunately, considerable overlap exists in EPO activity among normal animals, animals with primary erythrocytosis, and animals with secondary erythrocytosis. Furthermore, current availability of validated EPO assays for companion animals is limited. Routine examination of bone marrow is not useful to distinguish primary from secondary erythrocytosis because both conditions show erythroid hyperplasia. As a result, primary erythrocytosis usually is diagnosed by eliminating secondary causes.

To investigate types of secondary erythrocytosis, assessment of tissue oxygenation may be helpful. Arterial blood pO2 <80 mmHg and pulse oximetry oxygen saturation <90–95% are consistent with the hypoxemia and tissue hypoxia of app

To investigate types of secondary erythrocytosis, assessment of tissue oxygenation may be helpful. Arterial blood pO2 <80 mmHg and pulse oximetry oxygen saturation <90–95% are consistent with the hypoxemia and tissue hypoxia of appropriate compensatory response.

[[Category:Haematology Changes]]

[[Category:Haematology Changes]]