Changes

The virus replicates primarily in the upper respiratory tract, tonsils, or upper alimentary tract and there is '''aerosol''' excretion during this incubation period. This is then followed by a viremia. Virus targets stratum spinosum of stratified squamous epithelia and mucus membranes and secondary '''vesicles''' appear after incubation of 2-14 days. Lesions also affect the feet with cutaneous erosions in interdigital cleft, at coronet and bulbs of heals . These feet lesions often take a long time to heal as secondary bacterial infections may ensue and produce true deep ulcerative dermatitis. In the young, without maternal antibody, virus will localize in the heart, particularly the wall of the left ventricle, resulting in multi-focal necrosis of the myocardium and subsequent death. Persistent infection of cattle can occur in unkeratinized lesions, but subclinical carriers do not usually transfer infection except for subclinical buffalo that can transmit the disease.

The virus replicates primarily in the upper respiratory tract, tonsils, or upper alimentary tract and there is '''aerosol''' excretion during this incubation period. This is then followed by a viremia. Virus targets stratum spinosum of stratified squamous epithelia and mucus membranes and secondary '''vesicles''' appear after incubation of 2-14 days. Lesions also affect the feet with cutaneous erosions in interdigital cleft, at coronet and bulbs of heals . These feet lesions often take a long time to heal as secondary bacterial infections may ensue and produce true deep ulcerative dermatitis. In the young, without maternal antibody, virus will localize in the heart, particularly the wall of the left ventricle, resulting in multi-focal necrosis of the myocardium and subsequent death. Persistent infection of cattle can occur in unkeratinized lesions, but subclinical carriers do not usually transfer infection except for subclinical buffalo that can transmit the disease.

FMDV causes loss of condition and productivity but is NOT typically fatal. Aproximately 5% mortality (usually young animals); older animals recover. The virus is highly contagious and spread is by aerosol, direct contact, saliva, infected swill and fomites. Pigs produce 3000 times more aerosol virus than cows, but cows are much more susceptible to infection than pigs.

FMDV causes loss of condition and productivity but is NOT typically fatal. Approximately 5% mortality (usually young animals); older animals recover. The virus is highly contagious and spread is by aerosol, direct contact, saliva, infected swill and fomites. Pigs produce 3000 times more aerosol virus than cows, but cows are much more susceptible to infection than pigs.

In 1967 and 2001 there were major outbreaks in the UK. The disease is still widespread in many parts of world especially S. America and far East.

In 1967 and 2001 there were major outbreaks in the UK. The disease is still widespread in many parts of world especially S. America and far East.