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Liver - Anatomy & Physiology
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Revision as of 09:17, 17 July 2008
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*No valves so bile may flow in either direction
*No valves so bile may flow in either direction
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[[Image:Formation of Bile Acids.jpg|thumb|right|150px|Formation of Bile Acids - Copyright RVC 2008]]
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==Bile Acids==
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*Composed of cholesterol, bile acids and steroids
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*Main bile acid is cholic acid (C24)
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*Conjugated to taurine or glycine in the liver to reduce pKa so they exist in an ionised form as bile salts
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*Bile salts conjugate with cholesterol and phospholipids and are then secreted into the bile
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*95% are recycled in enterohepatic circulation
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*Emulsify fats
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*Helps absorb fat soluble vitamins
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*In aqueous solution form micelles which are amphiphilic and can transport free fatty acids across the brush border
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