Changes

==Structure==

==Structure==

<p>The spleen lies vertically on the left side of the cranial abdomen. It is attached to the greater curvature of the stomach by the greater omentum. The spleen is covered in a enclosed in a capsule of fibrous and elastic tissue that extends into the parenchyma as trabeculae.  </p>

<p>The spleen lies vertically on the left side of the cranial abdomen. It is attached to the greater curvature of the stomach by the greater omentum. The spleen is covered in a enclosed in a capsule of fibrous and elastic tissue that extends into the parenchyma as trabeculae.  </p>

<p> The parenchyma is supported by a fine mesh of reticular fibres and is divided into two types of tissue, the red and the white pulp.</p>

<p> The parenchyma is supported by a fine mesh of reticular fibres and is divided into two types of tissue, the red and the white pulp. The red and white pulp are separated by the marginal sinus.</p>

===Red Pulp===

===Red Pulp===

<p>The red pulp makes up the majority of the spleen and is composed of a network of cell cords in series with vascular sinuses. The splenic cords contain macrophages, plasma cells, lymphocytes and other mature blood cells e.g. granulocytes and erythrocytes.  While the vascular sinuses are wide vascular channels lined with endothelial cells. Blood cells and fluid can pass into the splenic cords through fenestrations in the sinus walls. </p>

<p>The red pulp makes up the majority of the spleen and is composed of a network of cell cords in series with vascular sinuses. The splenic cords contain macrophages, plasma cells, lymphocytes and other mature blood cells e.g. granulocytes and erythrocytes.  While the vascular sinuses are wide vascular channels lined with endothelial cells. Blood cells and fluid can pass into the splenic cords through fenestrations in the sinus walls. </p>

*Branches regularly as it passes through the spleen in horses and pigs

*Branches regularly as it passes through the spleen in horses and pigs

*Branches before it reaches the spleen in dogs and cats</p>

*Branches before it reaches the spleen in dogs and cats</p>

===Innervation===

===Innervation===

Innervation is purely sympathetic[[LH References - Anatomy & Physiology#Nance|^Ref:Nance]] and nerve fibres travel with the artery into the spleen.

Innervation is purely sympathetic[[LH References - Anatomy & Physiology#Nance|^Ref:Nance]] and nerve fibres travel with the artery into the spleen.

===Lymphatics===

===Lymphatics===

===Histology===

===Histology===

==Function==

==Function==

==In pathology==

==In pathology==

[[Lymphoreticular/Haemotopoietic System - Spleen|See here]]

[[Lymphoreticular/Haemotopoietic System - Spleen|See here]]