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* Take 2ml of clotted or heparinised blood
 
* Take 2ml of clotted or heparinised blood
 
* Inject TRH slowly i/v over 1 minute using the dose rates below. Please note: TRH can cause mild side effects such as defecation, salivation, tachypnoea. If these cause a problem, atropine is an effective antidote. Thyrotropin Releasing Hormone is available on prescription as TRH Cambridge Laboratories*.
 
* Inject TRH slowly i/v over 1 minute using the dose rates below. Please note: TRH can cause mild side effects such as defecation, salivation, tachypnoea. If these cause a problem, atropine is an effective antidote. Thyrotropin Releasing Hormone is available on prescription as TRH Cambridge Laboratories*.
 
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{| class="wikitable"
1-5kg 100μg TRH
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|+
 
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|1-5kg  
5-30kg 200μg TRH
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|100μg TRH
 
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|-
>30kg 300μg TRH
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|5-30kg
 +
|200μg TRH
 +
|-
 +
|>30kg
 +
|300μg TRH
 +
|}
    
* Take a second 2ml of clotted or heparinised blood 4 hours after TRH injection
 
* Take a second 2ml of clotted or heparinised blood 4 hours after TRH injection
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* If the pre-stimulation T4 is >25nmol/l, regardless of the post-stimulation concentration, the dog is normal
 
* If the pre-stimulation T4 is >25nmol/l, regardless of the post-stimulation concentration, the dog is normal
 
* With a pre-stimulation T4 <25nmol/l, the post-stimulation values can be interpreted as follows:
 
* With a pre-stimulation T4 <25nmol/l, the post-stimulation values can be interpreted as follows:
 
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{| class="wikitable"
0-20nmol/l Hypothyroid or sick euthyroid
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|+
 
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|0-20nmol/l  
20-30nmol/l Status equivocal
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|Hypothyroid or sick euthyroid
 
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|-
>30nmol/l Normal
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|20-30nmol/l
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|Status equivocal
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|-
 +
|>30nmol/l
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|Normal
 +
|}
    
* Dogs with equivocal values should be retested after 1 month
 
* Dogs with equivocal values should be retested after 1 month