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From a clinical standpoint, there is a rationale for synbiotic therapy alongside antibiotic use in both dogs and cats. It is well documented that antibiotics (e.g. metronidazole, enrofloxacin, clindamycin) can have a long-lasting and profound impact on the faecal microbiome that can take weeks, months or even years to recover.<ref name=":13">Pilla R, Gaschen FP, Barr JW, et al. Effects of metronidazole on the fecal microbiome and metabolome in healthy dogs. J Vet Intern Med 2020;34(5):1853-1866. </ref><ref name=":14">Whittemore JC, Price JM, Moyers T, Suchodolski JS. Effects of Synbiotics on the Fecal Microbiome and Metabolomic Profiles of Healthy Research Dogs Administered Antibiotics: A Randomized, Controlled Trial. Front Vet Sci 2021;8:665713.</ref> Concurrent synbiotic therapy can support greater recovery of both microbiome and metabolome (metabolites produced by the microbiome) composition after antibiotic discontinuation.<ref name=":14"/>  Furthermore, synbiotic supplementation has been shown to reduce the incidence of diarrhoea in dogs following entry into boarding kennels. Hence, the role of synbiotic therapy in improving animal welfare and increasing chances of rehoming, as well as decreasing the need for medical interventions, is relevant to many professionals in the animal health sector.<ref name=":15">Rose L, Rose J, Gosling S, Holmes M. Efficacy of a Probiotic-Prebiotic Supplement on Incidence of Diarrhea in a Dog Shelter: A Randomized, Double-Blind, Placebo-Controlled Trial. J Vet Intern Med 2017;31(2):377-382</ref>

From a clinical standpoint, there is a rationale for synbiotic therapy alongside antibiotic use in both dogs and cats. It is well documented that antibiotics (e.g. metronidazole, enrofloxacin, clindamycin) can have a long-lasting and profound impact on the faecal microbiome that can take weeks, months or even years to recover.<ref name=":13">Pilla R, Gaschen FP, Barr JW, et al. Effects of metronidazole on the fecal microbiome and metabolome in healthy dogs. J Vet Intern Med 2020;34(5):1853-1866. </ref><ref name=":14">Whittemore JC, Price JM, Moyers T, Suchodolski JS. Effects of Synbiotics on the Fecal Microbiome and Metabolomic Profiles of Healthy Research Dogs Administered Antibiotics: A Randomized, Controlled Trial. Front Vet Sci 2021;8:665713.</ref> Concurrent synbiotic therapy can support greater recovery of both microbiome and metabolome (metabolites produced by the microbiome) composition after antibiotic discontinuation.<ref name=":14"/>  Furthermore, synbiotic supplementation has been shown to reduce the incidence of diarrhoea in dogs following entry into boarding kennels. Hence, the role of synbiotic therapy in improving animal welfare and increasing chances of rehoming, as well as decreasing the need for medical interventions, is relevant to many professionals in the animal health sector.<ref name=":15">Rose L, Rose J, Gosling S, Holmes M. Efficacy of a Probiotic-Prebiotic Supplement on Incidence of Diarrhea in a Dog Shelter: A Randomized, Double-Blind, Placebo-Controlled Trial. J Vet Intern Med 2017;31(2):377-382</ref>

'''Author: Pippa Coupe BVSc, MRCVS Veterinary Product Manager at Protexin Veterinary. Protexin Veterinary is a brand of ADM Protexin Ltd'''

'''Author: Pippa Coupe BVSc, MRCVS Veterinary Product Manager at Protexin Veterinary. Protexin Veterinary is a brand of ADM Protexin Ltd'''  

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