Changes

<center><big>[[Pancreas|'''BACK TO PANCREAS''']]</big></center>

<center><big>[[Pancreas|'''BACK TO PANCREAS''']]</big></center>

<center><big>[[Pancreas - endocrine|'''BACK TO PANCREAS - ENDOCRINE''']]</big></center>

<center><big>[[Endocrine Pancreas - Pathology|'''BACK TO PANCREAS - ENDOCRINE''']]</big></center>

='''Diabetes mellitus'''=

='''Diabetes mellitus'''=

*Occurs in most species, most commonly in dog and cat

*Occurs in most species, most commonly in dog and cat

*Predisposed to [[Pancreas - inflammatory|pancreatitis]] and may also have [[EPI|pancreatic insufficiency]]

*Predisposed to [[Pancreas - inflammatory|pancreatitis]] and may also have [[EPI|pancreatic insufficiency]]

*Persistent [[Pancreas - endocrine#Glucagonoma|increase in glucagon]] may cause hyperglycaemia

*Persistent [[Endocrine Pancreas - Pathology#Glucagonoma|increase in glucagon]] may cause hyperglycaemia

*More common in mature dogs, twice as common in females than in males

*More common in mature dogs, twice as common in females than in males

===Aetiology===

===Aetiology===

Can be caused by

Can be caused by

*Absolute deficiency of insulin due to [[Pancreas - endocrine#Degenerative pathology|degenerative changes]] in beta cells (Miniature poodles, Dachsunds,Terriers seem to be predisposed)

*Absolute deficiency of insulin due to [[Endocrine Pancreas - Pathology#Degenerative pathology|degenerative changes]] in beta cells (Miniature poodles, Dachsunds,Terriers seem to be predisposed)

*Antagonism of insulin by hormones from the adrenal and thyroid glands, anterior pituitary causing high levels of blood glucose (e.g. progesterone may initiate postoestrus DM in the bitch, hyperadrenocorticism)

*Antagonism of insulin by hormones from the adrenal and thyroid glands, anterior pituitary causing high levels of blood glucose (e.g. progesterone may initiate postoestrus DM in the bitch, hyperadrenocorticism)

*Complication of pancreatic fibrosis

*Complication of pancreatic fibrosis