There are various hormones that may influence the structure of the skin. These influences may be made apparent by the repeated long-term administration of various glucocorticoids or their analogues. Endogenous imbalances are generally seen in adult mature animals although congenital forms have been seen, especially with [[Endocrine System - Thyroid Gland - Anatomy & Physiology#Problems associated with the Thyroid Gland|hypothyroidism]]. The hormones implicated as important for maintaining skin structure are '''thyroxine, cortisol''' and '''estradiol'''. Deficiencies or excessive production may result from abberations in the function of the [[Endocrine System - Adrenal Glands - Anatomy & Physiology|hypothalamic-adrenal axis]], the '''adrenal gland, thyroid gland''' and the '''gonads'''. | There are various hormones that may influence the structure of the skin. These influences may be made apparent by the repeated long-term administration of various glucocorticoids or their analogues. Endogenous imbalances are generally seen in adult mature animals although congenital forms have been seen, especially with [[Endocrine System - Thyroid Gland - Anatomy & Physiology#Problems associated with the Thyroid Gland|hypothyroidism]]. The hormones implicated as important for maintaining skin structure are '''thyroxine, cortisol''' and '''estradiol'''. Deficiencies or excessive production may result from abberations in the function of the [[Endocrine System - Adrenal Glands - Anatomy & Physiology|hypothalamic-adrenal axis]], the '''adrenal gland, thyroid gland''' and the '''gonads'''. |