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Immunodeficiencies - WikiBlood (view source)
Revision as of 10:49, 8 September 2008
, 10:49, 8 September 2008no edit summary
====Canine X-Linked Severe Combined Immune Deficiency (Canine SCID)====
====Canine X-Linked Severe Combined Immune Deficiency (Canine SCID)====
*Affects Basset Hounds and Corgis
*X-linked recessive defect in the gene conding for the IL-2 receptor
**IL-2 receptor is a receptor for the cytokine IL-2 which causes T cells to proliferate
*Causes lymphoid hypoplasia, stunted growth and increses the animal's susceptibility to infection
*Animal usually dies from pneumonia or sepsis as the level of maternal antibody decreases
====Selective IgA deficiency of German Shepherd Dogs====
====Selective IgA deficiency of German Shepherd Dogs====
*Poorly understood
*Linked to other disease syndromes such as deep pyoderma, inflammatory bowel disease, anal furunculosis and disseminated aspergillosis
*IgA deficiency so more susceptible to mucosal disease
====Immunodeficiency of Weimaraners====
====Immunodeficiency of Weimaraners, Irish Wolfhounds and Miniature Dachshunds====
*Unknown aetiology
*Inherited defects
*Low levels of circulating IgM and IgG
*Impaired neutrophil function
*Causes recurrent pyrexia and infections
**E.g. Rhinitis and bronchopneumonia in Irish Wolfhounds due to low IgA
**E.g. Pneumocytosis in Miniature Dachshunds due to low IgG
====Rhinitis/Bronchopneumonia in Irish Wolfhounds====
====Rhinitis/Bronchopneumonia in Irish Wolfhounds====