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Sertoli cells are those which act as ''nurse cells'' to the developing spermatozoa. The sertoli cells engulf the spermatozoa, are structurally important in the seminiferous tubules and form the blood-testis barrier.

Tumours are usually slow growing although 10-20% show malignant characteristics.
Neoplasia is predisposed by inguinal or abdominal testes.

Sertoli cell tumours usually present as a feminising syndrome in the elderly dog. Owners may also notice:
*Asymmetric testes.
*Swelling in one testis.
*Infertility/subfertility in a breeding dog.

Treatment involves castration. Metastasis is rare but can occur, in which case chemotherapy is a possible treatment option.