3,320
edits
Changes
→Mechanism of Action
==Mechanism of Action==
==Mechanism of Action==
Fluoroquinolones work by inhibiting bacterial DNA gyrase or the topoisomerase enzyme and thus inhibit bacterial DNA replication and transcription. The gyrase enzyme is usually the target in gram-negative bacteria, whilst the topoisomerase enzyme is the target in most gram-positive bacteria. This kills the bacteria and so the drug is a bactericidal and concentration dependent.
These drugs also have the ability to cross animal's cell membranes through porins. This means that this group of drugs is capable of acting upon intracellular pathogens.
==Spectrum of Activity==
==Spectrum of Activity==