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New page: {{review}} {{toplink |linkpage =WikiDrugs |linktext =WikiDrugs |sublink1 = Antibiotics |subtext1 = Antibiotics |pagetype = Drugs }} thumb|right|250px|Novobiocin ...
{{review}}
{{toplink
|linkpage =WikiDrugs
|linktext =WikiDrugs
|sublink1 = Antibiotics
|subtext1 = Antibiotics
|pagetype = Drugs
}}
[[Image: Novobiocin.png|thumb|right|250px|Novobiocin]]
Novobiocin is a '''coumarin''' antibiotic produced by ''Streptomyces''
==Mechanism of Action==
Novobiocin works by inhibiting bacterial DNA gyrase by acting as a competitive inhibitor of the ATPase reaction performed by the GyrB subunit of the gyrase enzyme.
==Spectrum of Activity==
It has a narrow spectrum mainly targeting gram-positive species.
* Very active against ''S.aureus''. It works less well against streptococci and fastidious gram-negatives.
* It is at its least active against enterbacteriaceae and ''Pseudomonas''.
* It works synergistically with [[Penicillins | Penicillin G]] against ''Staphs'' and ''Streps''. They are often combined in intramammary preperations, this is Novobiocin's only use in Veterinary medicine.
==Pharmacokinetic Considerations==
It isn't used systemically but only topically with other drugs to treat mastitis.
==Side Effects and Contraindications==
Some cows have experienced skin eruptions
{{toplink
|linkpage =WikiDrugs
|linktext =WikiDrugs
|sublink1 = Antibiotics
|subtext1 = Antibiotics
|pagetype = Drugs
}}
[[Image: Novobiocin.png|thumb|right|250px|Novobiocin]]
Novobiocin is a '''coumarin''' antibiotic produced by ''Streptomyces''
==Mechanism of Action==
Novobiocin works by inhibiting bacterial DNA gyrase by acting as a competitive inhibitor of the ATPase reaction performed by the GyrB subunit of the gyrase enzyme.
==Spectrum of Activity==
It has a narrow spectrum mainly targeting gram-positive species.
* Very active against ''S.aureus''. It works less well against streptococci and fastidious gram-negatives.
* It is at its least active against enterbacteriaceae and ''Pseudomonas''.
* It works synergistically with [[Penicillins | Penicillin G]] against ''Staphs'' and ''Streps''. They are often combined in intramammary preperations, this is Novobiocin's only use in Veterinary medicine.
==Pharmacokinetic Considerations==
It isn't used systemically but only topically with other drugs to treat mastitis.
==Side Effects and Contraindications==
Some cows have experienced skin eruptions