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Nitroimidazoles (view source)

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==Mechanism of Action==

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These drugs are bactericidal and concentration dependent killers and work by forming unstable products inside cells under '''anaerobic''' conditions.

==Spectrum of Activity==

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* Will kill nearly all anaerobic Gram-positive and negative bacteria.

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* Highly active against anaerobic protozoa, especially ''Treponema hyodysenteriae, Trichomonas foetus, Histomonas'' and ''Giardia''.

==Pharmacokinetic Considerations==

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They are small, lipid soluble molecules that are readily absorbed by the gastrointestinal tract. As such they have fantastic tissue penetration and can enter exclusive tissue such as the brain and the CSF.

==Side Effects and Contraindications==

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