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Chloramphenicol (view source)

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→‎Pharmacokinetic Considerations

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==Pharmacokinetic Considerations==

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Chloramphenicol and analogues: Highly lipophilic neutral small molecules.

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• Orally active.

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• Very wide volume of distribution – penetrates across cell membranes readily – the data shown on the slide are for penetration into bronchial secretions.

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Bronchial fluid is a transcellular fluid – what are the barriers for a drug to diffuse into this fluid?

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• Hepatic metabolism (varies between species and with age) for chloramphenicol.

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• A higher proportion of the administered dose of thiamphenicol and florphenicol are excreted unchanged in the urine.

==Side Effects and Contraindications==

==Florfenicol and Thiamphenicol==

Jtulloch

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