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==Pharmacokinetic Considerations==
 
==Pharmacokinetic Considerations==
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Chloramphenicol and analogues: Highly lipophilic neutral small molecules. 
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• Orally active.
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• Very wide volume of distribution – penetrates across cell membranes readily – the data shown on the slide are for penetration into bronchial secretions.
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Bronchial fluid is a transcellular fluid – what are the barriers for a drug to diffuse into this fluid?
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• Hepatic metabolism (varies between species and with age) for chloramphenicol. 
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• A higher proportion of the administered dose of thiamphenicol and florphenicol are excreted unchanged in the urine.
    
==Side Effects and Contraindications==
 
==Side Effects and Contraindications==
    
==Florfenicol and Thiamphenicol==
 
==Florfenicol and Thiamphenicol==
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