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====Pathogenesis====
 
====Pathogenesis====
*[[Respiratory Viral Infections - Pathology#Feline viral rhinotracheitis|Upper respiratory tract infection]] *
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*Upper respiratory tract infection: [[Respiratory Viral Infections - Pathology#Feline viral rhinotracheitis|Feline Viral Rhinotracheitis]]
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**Viruses and bacteria are involved in the complex
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** The most frequent aetiologic agent is FHV-1, and less frequently feline calicivirus and/or [[Chlamydia and Chlamydophila species|''Chlamydophia psittaci'']]
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**All three agents infect URT respiratory epithelium, although FHV-1 has the highest affinity for this epithelium
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***Feline calicivirus more frequently infects the oral mucosa -> ulcerative stomatitis
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***C.psittaci more frequently infects the conjunctival epithelium -> chronic conjunctivitis
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**Infection of the respiratory epithelium by FHV-1 results in a typical neutrophilic rhinitis with intraepitheial intranuclear eosinophilic inclusion bodies, with expected clinical signs
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**Resolution of clinical signs usually occurs by 7-14 days
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**FHV-1 remains '''latent''' in the trigeminal ganglion, and can reactivate at times of stress: Can infect the cornea -> ulcerative keratitis
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**Occasional mortality in kitten or immunocompromised animals usually associated with secondary bacterial infection
 
*Erosions can affect the bronchi, resulting in '''interstitial pneumonia'''
 
*Erosions can affect the bronchi, resulting in '''interstitial pneumonia'''
 
*Most common cause of '''keratitis''' and '''corneal ulcers''' in cat and '''gummy eyes''' in kittens
 
*Most common cause of '''keratitis''' and '''corneal ulcers''' in cat and '''gummy eyes''' in kittens
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