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→Modes of Action
==Modes of Action==
==Modes of Action==
These drugs mainly act on the parasites nervous system and neuromuscular junction. They are selectively toxic by having a greater affinity for the parasite receptor than the animal receptor. They can either by '''contact posions''' - arbsorbed through the parasites exoskeleton, or are '''stomach poisons''' - they are absorbed through the parasites stomach and so the parasite must bite to be affected. Thus the stomach poisons are usually given systemically to the host animal.
===Insecticides===
'''Synthetic Pyrethroids - Cypermethrin, Deltamethrin'''
* Many products and are in widespread use.
* They increase the permeability of neuronal membranes to sodium ions. This makes the membrane hyperxcitable leading to convulsions and death.
* In high concentrations these products can cause adverse reactions in cats and dogs.
* '''Piperonyl butoxide''' is a syngeristic product that is often put in formulations to potentiate the action of the pyrethroids.
'''Semicarbazones - Metaflumizone'''
* A new group of insecticides
* They work be blocking sodium ion channels in the axonal membrane of nerves, this prevents the propagation of nerve impulses leading to paralysis of the insect and hence death.
'''Organophosphates and Carbamates - Diazinon, Dichlorvos'''
* Their use has been limited of late as they are potentially neurotoxic to animals and man, and can cause environmental damage.
* They are anticholinesterases and so resukt in the build up of acetylcholine in the parasites's synapses, leading to paralysis and death.
'''Neonicotinoids - Imidacloprid, Nitenpyram'''
*