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→Safety
==Safety==
==Safety==
* These are on the whole safe drugs to use.
* But '''Collie type breeds''' of dogs, especially '''Rough Coated Collies''' can be fatal. This is because they can lack a efflux transporter protein that removes these drugs from the CNS. This means toxic concentrations are capable of accumulating.
* This can also occur when Ivermectin is used at the higher doses needed for some heartworm therapies.
* They are often in high concentrations in faeces, this means that bettles and other insects that use dung-pats for their development can be killed. This is currently a heated topic, especially in areas of a delicate ecosystem.