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→Pharmacokinetics
* In ruminants, the potency is increased by starving them for 12-24 hours, as the transit time through the gut will be increased. This is the opposite in carnivores.
* In ruminants, the potency is increased by starving them for 12-24 hours, as the transit time through the gut will be increased. This is the opposite in carnivores.
* These drugs are often given in a pro-drug form which is metabolised to the sulphoxide form of the drug (the most potent form) and then to the inactive sulphone form. '''Netobimin''' is the prodrug of albendazole, whilst '''febantel''' is the prodrug fenbendazole.
* These drugs are often given in a pro-drug form which is metabolised to the sulphoxide form of the drug (the most potent form) and then to the inactive sulphone form. '''Netobimin''' is the prodrug of albendazole, whilst '''febantel''' is the prodrug fenbendazole.
==Safety==
* Some members of this group are '''tetragenic'''. Thus they should not be used in pregnant animals.