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→Pharmacokinetic Considerations
==Pharmacokinetic Considerations==
==Pharmacokinetic Considerations==
Pharmacokinetics for NSAIDs differ greatly between species, meaning that data from one species cannot be used to reliably calculate a dose for another. An example of such a variation is provided by phenylbutazone, which has zero-order kinetics in some species (including the dog), but first order kinetics in others. This means the half-life of this drug is variable and unpredictable.
NSAIDs may be administered orally or parentally. As they are weak acids, NSAIDs are well absorbed following oral administration. The presence of food may, however, interfere with this absorption.
Non-steroidal anti-inflammatory drugs have a high degree of plasma protein binding (approaching 99%). This means that other highly plasma protein-bound drugs with stronger binding affinities may displace NSAIDs from their binding. This would lead to an increase in circulating free drug levels and hence potential overdose. Although this is a theoretical risk, it has been demonstrated in relation to warfarin administration.
==Side Effects and Contraindications==
==Side Effects and Contraindications==