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Local Anaesthetics (view source)

Revision as of 20:01, 26 February 2009

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→‎Pharmacokinetic Considerations

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==Pharmacokinetic Considerations==

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Local anaesthetics are weak bases, and may be ionised or unisonised. The unionised form is more hydrophobic, and so will more easily cross the plasma membrane enter the cell. At body pH of 7.4, more local anaesthetic drug molecules are ionised than unionised, which is not ideal. The drugs also find it harder to enter infected tissue because it has a lower pH, giving more ionised molecules.

==Side Effects and Contraindications==

==Drugs in this Group==

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