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Muscles Degenerative - Pathology (view source)
Revision as of 20:28, 13 August 2009
, 20:28, 13 August 2009no edit summary
*Occur following many different types of insult and are usually '''segmental'''
*Occur following many different types of insult and are usually '''segmental'''
*If regeneration does not occur after formation of small vacuoles, [[Muscles Degenerative - Pathology#Necrosis|necrosis]] follows
*If regeneration does not occur after formation of small vacuoles, [[Muscles Degenerative - Pathology#Necrosis|necrosis]] follows
**Vacuolation -> floccular degeneration -> granular degeneration -> [[General Pathology - Degenerations and Infiltrations#Hyaline Degeneration|hyaline]] and [[Zenker Degeneration - Pathology|Zenker’s degeneration]]
**Vacuolation -> floccular degeneration -> granular degeneration -> [[Degenerations and Infiltrations - Pathology#Hyaline Degeneration|hyaline]] and [[Zenker Degeneration - Pathology|Zenker’s degeneration]]
*[[General Pathology - Degenerations and Infiltrations#Vacuolar Degeneration|'''Vacuolar degeneration''']]:
*[[Degenerations and Infiltrations - Pathology#Vacuolar Degeneration|'''Vacuolar degeneration''']]:
**Due to swelling of organelles or due to glycogen or fat accumulation
**Due to swelling of organelles or due to glycogen or fat accumulation
**May be caused by hypokalaemia, hyperkalaemia or necrosis
**May be caused by hypokalaemia, hyperkalaemia or necrosis
*Due to:
*Due to:
**Old age - myofibres
**Old age - myofibres
**Following necrosis - [[General Pathology - Pigmentation and Calcification#Dystrophic|dystrophic calcification]]
**Following necrosis - [[Pigmentation and Calcification - Pathology#Dystrophic|dystrophic calcification]]
***May be visible grossly as white foci
***May be visible grossly as white foci
**Seen in horses and dogs
**Seen in horses and dogs
**Histologically:
**Histologically:
***Central zone - proliferating undifferentiated cells and [[General Pathology - Chronic Inflammation#Fibroblasts|fibroblasts]]
***Central zone - proliferating undifferentiated cells and [[Chronic Inflammation - Pathology#Fibroblasts|fibroblasts]]
***Middle zone - [[Bones - normal#Normal structure|osteoblasts]] depositing osteoid and bone
***Middle zone - [[Bones - normal#Normal structure|osteoblasts]] depositing osteoid and bone
***Outer zone - [[Bones - normal#Bone organisation|trabecular bone]] remodelled by [[Bones - normal#Normal structure|osteoclasts]]
***Outer zone - [[Bones - normal#Bone organisation|trabecular bone]] remodelled by [[Bones - normal#Normal structure|osteoclasts]]
===Pigmentation===
===Pigmentation===
*[[General Pathology - Pigmentation and Calcification#Lipofuscin|'''Lipofuscin''']]
*[[Pigmentation and Calcification - Pathology#Lipofuscin|'''Lipofuscin''']]
**Wear and tear pigment accumulating in secondary lisosomes -> converted into compact residual bodies
**Wear and tear pigment accumulating in secondary lisosomes -> converted into compact residual bodies
**Due to old age, past or recent cachexia or starvation
**Due to old age, past or recent cachexia or starvation
**Histologically:
**Histologically:
***Rounded yellow to brown granules at both poles of nucleus of the skeletal myofiber
***Rounded yellow to brown granules at both poles of nucleus of the skeletal myofiber
*[[General Pathology - Pigmentation and Calcification#Melanin|'''Melanin''']]
*[[Pigmentation and Calcification - Pathology#Melanin|'''Melanin''']]
**As part of congenital melanosis of calves in fascial sheaths and epimysium
**As part of congenital melanosis of calves in fascial sheaths and epimysium
**Grossly - black foci
**Grossly - black foci
***[[Dirofilaria immitis|''Dirofilaria immitis'']] arteritis in dogs
***[[Dirofilaria immitis|''Dirofilaria immitis'']] arteritis in dogs
***Vasculitis due to [[Reoviridae#Bluetongue Virus|bluetongue virus]] in sheep
***Vasculitis due to [[Reoviridae#Bluetongue Virus|bluetongue virus]] in sheep
***[[General Pathology - Haemorrhage#Purpura haemorrhagica|'''Equine purpura haemorrhagica''']]
***[[Haemorrhage - Pathology#Purpura haemorrhagica|'''Equine purpura haemorrhagica''']]
****Non-contagious, sporadic
****Non-contagious, sporadic
****Grossly:
****Grossly: