Changes

==Description==

==Description==

Chronic hepatitis is an inflammatory-necrotising disease of at least 6 months duration.  It is characterised by hepatocellular apoptosis or necrosis, a variable mononuclear or mixed inflammatory cell infiltrate, regeneration and fibrosis (1).  It predominantly consists of lymphocytic-plasmacytic inflammatory infiltration.   

'''Chronic hepatitis''' is an inflammatory-necrotising disease of at least 6 months duration.  It is characterised by hepatocellular apoptosis or necrosis, a variable mononuclear or mixed inflammatory cell infiltrate, regeneration and fibrosis (1).  It predominantly consists of lymphocytic-plasmacytic inflammatory infiltration.   

A number of aetiologies include:

A number of aetiologies include:

**This may be a cause or consequence of chronic hepatitis.  Copper is normally excreted in bile, therefore it can occur with any cholestatic hepatobiliary disorder.

**This may be a cause or consequence of chronic hepatitis.  Copper is normally excreted in bile, therefore it can occur with any cholestatic hepatobiliary disorder.

*Chronic drug therapy

*Chronic drug therapy

*Infectious, for example infectious canine hepatitis-

*Infectious, for example infectious canine hepatitis

*Autoimmune or steroid responsive disorder

*Autoimmune or steroid responsive disorder