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Cholangitis, Neutrophilic (view source)
Revision as of 15:50, 20 August 2009
, 15:50, 20 August 2009→Diagnosis
*depression and lethargy
*depression and lethargy
*abdominal pain
*abdominal pain
*jaundice
*[[Liver General Pathology - Pathology|jaundice]]
*dehydration
*dehydration
===Laboratory Tests===
===Laboratory Tests===
====Haematology====
====Haematology====
*Mild neutrophilia with left shift
*Mild [[Changes in Inflammatory Cells Circulating in Blood - Pathology #Neutrophilia|neutrophilia]] with left shift
====Biochemistry====
====Biochemistry====
*Increased alanine aminotransferase (ALT)
*Increased alanine aminotransferase (ALT)
===Diagnostic Imaging===
===Diagnostic Imaging===
A coarse or nodular texture to the liver on ultrasonography. However, most have variable or no detectable changes in echogenicity of the liver parenchyma. More chronic cases may have dilation of the biliary tract.
====Ultrasonography====
A coarse or nodular texture to the liver can be seen. However, most have variable or no detectable changes in echogenicity of the liver parenchyma. More chronic cases may have dilation of the biliary tract.
===Histopathology===
===Histopathology===
Liver cytology or tissue biopsy is required to differentiate inflammatory liver disease from hepatic lipidosis and neoplasia. Bile samples for cytology is needed for a definitive diagnosis. It is not adequate to perform liver biopsy alone as the disease tend to be confined to the biliary tract and pathology of the liver can be non specific and mild. Cytologically, neutrophilic cholangitis usually shows bacteria and neutrophils. Culture and sensitivity should be performed for appropriate choice of antibiotics.
Liver cytology or tissue biopsy is required to differentiate inflammatory liver disease from [[Hepatic Lipidosis - WikiClinical|hepatic lipidosis]] and [[Neoplasia - Pathology|neoplasia]]. Bile samples for cytology is needed for a definitive diagnosis. It is not adequate to perform liver biopsy alone as the disease tend to be confined to the biliary tract and pathology of the liver can be non specific and mild. Cytologically, neutrophilic cholangitis usually shows bacteria and [[Neutrophils - WikiBlood|neutrophils]]. Culture and sensitivity should be performed for appropriate choice of antibiotics.
==Treatment==
==Treatment==