Changes

===Methadone===

===Methadone===

Methadone is an unlicensed, Schedule 2 controlled, full OP3 agonist. It is used i/v, i/m, s/c or by constant rate infusion for the relief of moderate to severe pain. Advantageously, it does not cause emesis.

Methadone is an unlicensed, Schedule 2 controlled, full OP3 agonist. It is used i/v, i/m, s/c or by constant rate infusion for the relief of moderate to severe pain. Advantageously, it does not cause emesis. There is an onset time of 15-30 mins following i/v, i/m or s/c administration, and effects then last for around 4 hours.

===Fentanyl===

===Fentanyl===