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| ====Pus Formation==== | | ====Pus Formation==== |
| | | |
− | * Occurs when the organism causing the initial necrosis in the tissue is capable of attracting and killing large numbers of [[Neutrophils - WikiBlood|neutrophils]]. | + | * Occurs when the organism causing the initial necrosis in the tissue is capable of attracting and killing large numbers of [[Neutrophils - WikiBlood|[[Neutrophils - WikiBlood|neutrophils]]]]. |
| ** I.e the '''pyogenic bacteria'''. | | ** I.e the '''pyogenic bacteria'''. |
| * [[Neutrophils - WikiBlood|Neutrophils]] release proteolytic enzymes when they die. | | * [[Neutrophils - WikiBlood|Neutrophils]] release proteolytic enzymes when they die. |
− | ** These digest the dead tissue and also more incoming neutrophils. | + | ** These digest the dead tissue and also more incoming [[Neutrophils - WikiBlood|neutrophils]]. |
| *** The liquid formed is called '''pus'''. | | *** The liquid formed is called '''pus'''. |
− | * Pus is mainly composed of dead and dying neutrophils . | + | * Pus is mainly composed of dead and dying [[Neutrophils - WikiBlood|neutrophils]] . |
| ** Also contains the remnants of the necrotic tissue cells. | | ** Also contains the remnants of the necrotic tissue cells. |
− | * Although in favourable cases the neutrophils may eventually kill the organisms, in most cases the organisms persist, producing more pus. | + | * Although in favourable cases the [[Neutrophils - WikiBlood|neutrophils]] may eventually kill the organisms, in most cases the organisms persist, producing more pus. |
| ** Produces an expanding sphere of pus known as an [[Acute Inflammation - Pathology#Purulent|'''abscess''']]. | | ** Produces an expanding sphere of pus known as an [[Acute Inflammation - Pathology#Purulent|'''abscess''']]. |
| *** If the abscess is near to the skin and pressure becomes sufficient after build up, it will burst. | | *** If the abscess is near to the skin and pressure becomes sufficient after build up, it will burst. |
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| =====Histological Appearance of an Abscess===== | | =====Histological Appearance of an Abscess===== |
| | | |
− | * The necrotic area shows varying stages of degeneration of the neutrophils. | + | * The necrotic area shows varying stages of degeneration of the [[Neutrophils - WikiBlood|neutrophils]]. |
− | ** Ranges from nearly normal neutrophils, through pyknosis, karyorrhexis and karyolysis, finally to a homogenous, structureless, mixture of remnants. | + | ** Ranges from nearly normal [[Neutrophils - WikiBlood|neutrophils]], through pyknosis, karyorrhexis and karyolysis, finally to a homogenous, structureless, mixture of remnants. |
| *** Stains faintly bluish. | | *** Stains faintly bluish. |
| * There is a host inflammatory response directed against the sphere of pus as it is forming. | | * There is a host inflammatory response directed against the sphere of pus as it is forming. |
| ** Results in a capsule of fibrous tissue which has many blood vessels on its inner surface. | | ** Results in a capsule of fibrous tissue which has many blood vessels on its inner surface. |
− | *** Allows the transport of the vast number of neutrophils into the necrotic centre. | + | *** Allows the transport of the vast number of [[Neutrophils - WikiBlood|neutrophils]] into the necrotic centre. |
| *** Known as the 'pyogenic membrane'. | | *** Known as the 'pyogenic membrane'. |
| *** Can be viewed following abscess discharge as a crater that has a reddish, somewhat ragged lining. | | *** Can be viewed following abscess discharge as a crater that has a reddish, somewhat ragged lining. |