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Created page with '*Infect a wide range of fish and animals **Including humans ***Causes severe diarrhoea in immunocompromised patients *Intracellular parasites…'
*Infect a wide range of fish and animals
**Including humans
***Causes severe [[Intestine Diarrhoea - Pathology|diarrhoea]] in immunocompromised patients
*Intracellular parasites
*Produce resistant spores
**Mature organism
**Contains a polar filament (coiled tube)
*''Encephalitozoon cuniculi''
**Found particularly in laboratory and pet rabbits
'''Life Cycle'''
*Spores are ingested
*Infects mucosal cells
**Polar filament pushed through the host cell walls
*Contents of the spore enter the host cell and multiply
**Differentiates into spores
**Spreads to target organs
**Infects [[Macrophage|macrophages]]
*Spores infect other host cells or are passed out via the faeces, urine or respiratory secretions
'''Pathogenesis'''
*Cells rupture
**Causes a granulomata in target organ
*Chronic disease
'''Diagnosis'''
*Clinical signs
**Head tilt, incontinence, uveitis, cataracts
**In most cases is asymptomatic
*Serology
**ELISA
*Post-mortem
**Granuloma
'''Control and Treatment'''
*Fenbendazole licensed for use in rabbits
*Cull seropositive animals
*Strict hygiene
**Raise foodbowls and water bottles off ground
**Do not use tiered hutches[[Category:Protozoa]]
**Including humans
***Causes severe [[Intestine Diarrhoea - Pathology|diarrhoea]] in immunocompromised patients
*Intracellular parasites
*Produce resistant spores
**Mature organism
**Contains a polar filament (coiled tube)
*''Encephalitozoon cuniculi''
**Found particularly in laboratory and pet rabbits
'''Life Cycle'''
*Spores are ingested
*Infects mucosal cells
**Polar filament pushed through the host cell walls
*Contents of the spore enter the host cell and multiply
**Differentiates into spores
**Spreads to target organs
**Infects [[Macrophage|macrophages]]
*Spores infect other host cells or are passed out via the faeces, urine or respiratory secretions
'''Pathogenesis'''
*Cells rupture
**Causes a granulomata in target organ
*Chronic disease
'''Diagnosis'''
*Clinical signs
**Head tilt, incontinence, uveitis, cataracts
**In most cases is asymptomatic
*Serology
**ELISA
*Post-mortem
**Granuloma
'''Control and Treatment'''
*Fenbendazole licensed for use in rabbits
*Cull seropositive animals
*Strict hygiene
**Raise foodbowls and water bottles off ground
**Do not use tiered hutches[[Category:Protozoa]]