Author, Donkey, Bureaucrats, Administrators
53,803
edits
Changes
Created page with '=== '''''TRICHURIS SUIS''''' === *A typical whipworm. *Prefers warmer climates and therefore only rarely a problem in the UK. *Disease mainly seen in pigs kept outdoors or in dee…'
=== '''''TRICHURIS SUIS''''' ===
*A typical whipworm.
*Prefers warmer climates and therefore only rarely a problem in the UK.
*Disease mainly seen in pigs kept outdoors or in deep-litter systems.
==== Pathogenesis ====
*Can provoke severe diarrhoea or dysentery by providing a portal of entry for microbial organisms (particularly spirochaetes).
==== Use in Human Medicine ====
*In experimental models, ''Trichuris'' markedly increases T-regulatory activity, thereby suppressing some immune-mediated diseases (Th2 responses increased; Th1 responses decreased).
*There's a theory that some human immune-mediated diseases are largely restricted to affluent developed countries (like inflammatory bowel disease and Crohn's disease) occur because the human immune system has evolved with T-regulating helminths constantly present, and therefore tends to go into overdrive in some individuals if this external regulatory influence is lacking.
*This had led to the hypothesis that strictly controlled exposure of selected human patients to T. suis might ameliorate the symptoms of chronic bowel disease.
*Large scale clinical trials (placebo-controlled cross-over studies) are currently in progress to test this hypothesis.[[Category:Trichinelloidea]][[Category:Pig_Nematodes]]
*A typical whipworm.
*Prefers warmer climates and therefore only rarely a problem in the UK.
*Disease mainly seen in pigs kept outdoors or in deep-litter systems.
==== Pathogenesis ====
*Can provoke severe diarrhoea or dysentery by providing a portal of entry for microbial organisms (particularly spirochaetes).
==== Use in Human Medicine ====
*In experimental models, ''Trichuris'' markedly increases T-regulatory activity, thereby suppressing some immune-mediated diseases (Th2 responses increased; Th1 responses decreased).
*There's a theory that some human immune-mediated diseases are largely restricted to affluent developed countries (like inflammatory bowel disease and Crohn's disease) occur because the human immune system has evolved with T-regulating helminths constantly present, and therefore tends to go into overdrive in some individuals if this external regulatory influence is lacking.
*This had led to the hypothesis that strictly controlled exposure of selected human patients to T. suis might ameliorate the symptoms of chronic bowel disease.
*Large scale clinical trials (placebo-controlled cross-over studies) are currently in progress to test this hypothesis.[[Category:Trichinelloidea]][[Category:Pig_Nematodes]]