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Diagnosis is dependent on:
 
Diagnosis is dependent on:
 
*History - dietary and environmental evaluation; directed towards identifying possible causes of calcium and vitamine D3 deficiency.
 
*History - dietary and environmental evaluation; directed towards identifying possible causes of calcium and vitamine D3 deficiency.
*Physical examination  
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*[[Lizard Physical Examination|Physical examination]]
 
*Radiography - hypomineralisation of skeleton, pathological fractures, fibrous osteodystrophy. Radiographs are very effective in confirming the diagnosis; indeed, radiolucent transverse processes in the caudal vertebrae are pathognomonic of MBD in lizards.
 
*Radiography - hypomineralisation of skeleton, pathological fractures, fibrous osteodystrophy. Radiographs are very effective in confirming the diagnosis; indeed, radiolucent transverse processes in the caudal vertebrae are pathognomonic of MBD in lizards.
 
*Biochemistry - [[Calcium|calcium]] is generally within normal limits but may be low, especially in neurological cases; the calcifediol assay can be done on plasma to determine the status.
 
*Biochemistry - [[Calcium|calcium]] is generally within normal limits but may be low, especially in neurological cases; the calcifediol assay can be done on plasma to determine the status.
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