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===[[Respiratory Bacterial Infections - Pathology#Contagious bovine pleuropneumonia (CBPP)|Contagious bovine pleuropneumonia]]===

*[[Respiratory Bacterial Infections - Pathology#Contagious bovine pleuropneumonia (CBPP)|Contagious bovine pleuropneumonia]] is caused by ''M. mycoides'' subsp. ''mycoides'' small colony type
*A severe contagious disease of cattle
*Endemic in Africa, the Middle East and Asia
*Aerosol transmission by close contact with clinically or subclinically affected animals
*Severity depends on strain and host susceptibility
*Slow spread of infection
*50% morbidity; mortality rate high in severe outbreaks
*Large colony type causes pleuropneumonia, mastitis, septicaemia and polyarthritis

*Clinical signs
**Acute onset fever, anorexia, depression, lowered milk yield, hyperpnoea, coughing and a mucopurulent nasal discharge
**Dyspnoea occurs with abducted elbows and extended necks and an expiratory grunt
**Can be fatal within 1-3 weeks
**Calves may suffer from [[Joints Inflammatory - Pathology#In Cattle|arthritis]], synovitis and endocarditis

*Gross pathology
**Marbled appearance to lungs with consolidated grey and red lobules separated by emphysematous areas
**Serofibrinous pleural fluid
**Necrotic foci surrounded by fibrous capsules in chronic cases act as source of infection

*Diagnosis
**Clinical signs and post-mortem appearance
**PCR on pleural fluid, lung tissue, regional lymph nodes or bronchoalveolar lavage fluid
**Fluorescent antibody test
**Serological tests such as serum agglutination, haemagglutination, complement fixation, ELISA

*Treatment and control
**Slaughter of affected cattle in counries where the disease is exotic
**Movement restrictions, quaranteen and slaughter of carrier animals in endemic countries
**Vaccination in endemic regions[[Category:Mycoplasmas]][[Category:Cattle]]
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