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Villus atrophy with damage to crypts (view source)
Revision as of 11:05, 6 June 2010
, 11:05, 6 June 2010Created page with '* The primary insult is to crypt cells. ** Crypt cell death leads to dilated gland lumens (cysts). ** Production is impaired, eventually leading to insufficient cells for villi. …'
* The primary insult is to crypt cells.
** Crypt cell death leads to dilated gland lumens (cysts).
** Production is impaired, eventually leading to insufficient cells for villi.
* Enterocytes lost to lumen are replaced by increasingly immature cells.
** Gives rise to severe malabsorption.
* If damage is severe, erosions/ulcers may form which may eventually heal.
** Even if there are no ulcers, damage can be long-term
*** Causes long-term malabsorption.
* Examples include:
** '''Parvovirus'''
*** Target crypt cells.
** '''Lymphoma'''
*** Numerous neoplastic lymphocytes compress crypts.
** '''Cytotoxic chemicals'''
*** Dividing crypt cells are susceptible.
[[Category:Enteritis,_Villus_Atrophy]]
** Crypt cell death leads to dilated gland lumens (cysts).
** Production is impaired, eventually leading to insufficient cells for villi.
* Enterocytes lost to lumen are replaced by increasingly immature cells.
** Gives rise to severe malabsorption.
* If damage is severe, erosions/ulcers may form which may eventually heal.
** Even if there are no ulcers, damage can be long-term
*** Causes long-term malabsorption.
* Examples include:
** '''Parvovirus'''
*** Target crypt cells.
** '''Lymphoma'''
*** Numerous neoplastic lymphocytes compress crypts.
** '''Cytotoxic chemicals'''
*** Dividing crypt cells are susceptible.
[[Category:Enteritis,_Villus_Atrophy]]