*Management of endogenous waste, e.g haem (Hb, cytochromes, Mb) and ammonia (amino acids)
*Management of endogenous waste, e.g haem (Hb, cytochromes, Mb) and ammonia (amino acids)
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−
===Acinus===
−
−
*the smallest functional unit of the [[Liver - Anatomy & Physiology|liver]] - this unit stresses the dependence of the [[Liver - Anatomy & Physiology|liver]] on its afferent blood vessels and efferent bile ducts
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*a roughly diamond shaped parenchymal mass surrounding and supplied by the portal area
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*consists of 3 zones:
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**Zone 1 - periportal (centroacinar), around the portal areas
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**Zone 2 - midzonal
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**Zone 3 - centrilobular (periacinar), bordering the hepatic venules
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NB: blood enters from Zone 1 to Zone 3 and thus becomes less and less oxygenated
Line 225:
Line 215:
*Kupfer macrophages present near the lining of the sinusoids
*Kupfer macrophages present near the lining of the sinusoids
+
+
===Acinus===
+
+
*the smallest functional unit of the [[Liver - Anatomy & Physiology|liver]] - this unit stresses the dependence of the [[Liver - Anatomy & Physiology|liver]] on its afferent blood vessels and efferent bile ducts
+
*a roughly diamond shaped parenchymal mass surrounding and supplied by the portal area
+
*consists of 3 zones:
+
**Zone 1 - periportal (centroacinar), around the portal areas
+
**Zone 2 - midzonal
+
**Zone 3 - centrilobular (periacinar), bordering the hepatic venules
+
NB: blood enters from Zone 1 to Zone 3 and thus becomes less and less oxygenated