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− | {{toplink
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− | |backcolour = FAFAD2
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− | |linkpage =Endocrine System - Pathology
| + | ==[[Pancreas, Endoscrine - Degenerative Pathology]]== |
− | |linktext =Endocrine System
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− | |maplink = Endocrine System (Content Map) - Pathology
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− | |pagetype =Pathology
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− | |sublink1=Pancreas - Pathology
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− | |subtext1=PANCREAS PATHOLOGY
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− | }}
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− | <br>
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− | ==Anatomy and Physiology==
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− | Anatomy and Physiology of the pancreas can be found [[Pancreas - Anatomy & Physiology|here]].
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− | ==Degenerative pathology== | |
− | ===Aetiology===
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− | *Hypoplasia of [[Pancreas - Anatomy & Physiology#Endocrine|panceatic islets]] where [[Pancreas - Anatomy & Physiology|exocrine]] cells are functional
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− | *Degeneration of the [[Pancreas - Anatomy & Physiology#Endocrine|islet]] cells occurs in [[Pancreatic Necrosis, Acute|acute pancreatic necrosis]] along with acinar tissue necrosis, atrophy occurs during [[Pancreatitis, Chronic Interstitial|chronic interstitial pancreatitis]]
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− | *Extensive neoplastic destruction may also contribute to [[Pancreas - Anatomy & Physiology#Endocrine|islet]] loss
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− | *Causes [[DM|Diabetes mellitus]] (DM)
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− | *In cats
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− | **'''Amyloidosis''' of the [[Pancreas - Anatomy & Physiology#Endocrine|islets]] is sometimes observed and may be restricted to just them
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− | ***May result in signs of [[DM|DM]] or have no symptoms
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− | ***[[Degenerations and Infiltrations - Pathology#Vacuolar Degeneration|Hydropic (vacuolar) degeneration]] of beta cells
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− | ***Acumultion of glycogen within the cytoplasm
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− | ***Develops in response to long-term overstimulation due to peripheral insulin resistance
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− | *In dogs
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− | **'''Sclerosis''' of the islets is sometimes observed in dogs with [[DM|DM]] without pancreatic necrosis but also in dogs without DM
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− | <br>
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− | '''For degeneration of exocrine tissue''' see [[:Category:Pancreas - Degenerative Pathology|'degenerative disease of exocrine pancreas in Alimentary section']]
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| ==Neoplasia== | | ==Neoplasia== |
| [[Image:Islet cell tumour.jpg|right|thumb|100px|<small><center>Islet cell tumour (Image sourced from Bristol Biomed Image Archive with permission)</center></small>]] | | [[Image:Islet cell tumour.jpg|right|thumb|100px|<small><center>Islet cell tumour (Image sourced from Bristol Biomed Image Archive with permission)</center></small>]] |