Changes

**Stimulate immune response on reaching the lamina propria

**Stimulate immune response on reaching the lamina propria

**Acute inflammation, possibly with ulceration; prostaglandin and cytokine production by epithelial cells; enterotoxin production damaging mucosa  

**Acute inflammation, possibly with ulceration; prostaglandin and cytokine production by epithelial cells; enterotoxin production damaging mucosa  

**Phagocytosis of bacteria by [[Neutrophils - WikiBlood|neutrophils]] and macrophages

**Phagocytosis of bacteria by [[Neutrophils|neutrophils]] and macrophages

**Bacteria either destroyed by the phagocytic cells or survive and multiply in the cells to cause systemic disease

**Bacteria either destroyed by the phagocytic cells or survive and multiply in the cells to cause systemic disease

**Resistance to phagocytosis and destruction by complement allows spread within the body - bacteraemia and septicaemia

**Resistance to phagocytosis and destruction by complement allows spread within the body - bacteraemia and septicaemia