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Text replace - 'Neutrophils - WikiBlood' to 'Neutrophils'
Immunological mechanisms may be of value. There are anecdotal reports of the benefits of '''autologous blood injections''' but it is very hard to see any immunological benefit from this approach. The reality is that a '''few cases do seem to resolve spontaneously''' (although this seems to be less common in donkeys than in horses).
Immunological mechanisms may be of value. There are anecdotal reports of the benefits of '''autologous blood injections''' but it is very hard to see any immunological benefit from this approach. The reality is that a '''few cases do seem to resolve spontaneously''' (although this seems to be less common in donkeys than in horses).
The use of '''intra-lesional BCG''' has been advocated and this appears to be a useful, but by no means certain, treatment for '''localised nodular and fibroblastic lesions around the eyes''' of the donkey. The critical factors appear to be the true intra-lesional injection; peri-lesional injection has no material benefit and risks the development of anaphylaxis. The mechanism for the effects of BCG are probably due to its intense chemotactic nature: macrophages and [[Neutrophils - WikiBlood|neutrophils]] and some mononuclear cells are actively drawn into the site and remove cells to which the BCG has adhered. Repeated injections are required and, as the tumour becomes necrotic and decays, true intra-lesional injection becomes more difficult.
The use of '''intra-lesional BCG''' has been advocated and this appears to be a useful, but by no means certain, treatment for '''localised nodular and fibroblastic lesions around the eyes''' of the donkey. The critical factors appear to be the true intra-lesional injection; peri-lesional injection has no material benefit and risks the development of anaphylaxis. The mechanism for the effects of BCG are probably due to its intense chemotactic nature: macrophages and [[Neutrophils|neutrophils]] and some mononuclear cells are actively drawn into the site and remove cells to which the BCG has adhered. Repeated injections are required and, as the tumour becomes necrotic and decays, true intra-lesional injection becomes more difficult.
===Cytotoxic compounds===
===Cytotoxic compounds===