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Text replace - 'Basophils - WikiBlood' to 'Basophils'
* Antigens that induce a type I reaction are known as allergens.
* Antigens that induce a type I reaction are known as allergens.
* Generally affects face, eyes, nose and feet
* Generally affects face, eyes, nose and feet
* [[Immunoglobulin E - WikiBlood|IgE]] has a high affinity to IgE receptors on [[Mast Cells - WikiBlood|mast cells]] and [[Basophils - WikiBlood|basophils]], and so binds these receptors.
* [[Immunoglobulin E - WikiBlood|IgE]] has a high affinity to IgE receptors on [[Mast Cells - WikiBlood|mast cells]] and [[Basophils|basophils]], and so binds these receptors.
==Common allergens which elict a type I hypersensitivity reaction:==
==Common allergens which elict a type I hypersensitivity reaction:==
'''2. Subsequent exposure to the specific allergen (Image 2):'''
'''2. Subsequent exposure to the specific allergen (Image 2):'''
* [[Mast Cells - WikiBlood|Mast cells]] degranulate.
* [[Mast Cells - WikiBlood|Mast cells]] degranulate.
* [[Basophils - WikiBlood|Basophils]] with [[Immunoglobulin E - WikiBlood|IgE]] receptors are recruited and also degranulate.
* [[Basophils|Basophils]] with [[Immunoglobulin E - WikiBlood|IgE]] receptors are recruited and also degranulate.
* The release of inflammatary [[Cytokines - WikiBlood|cytokines]] which can cause the dog to become itchy.
* The release of inflammatary [[Cytokines - WikiBlood|cytokines]] which can cause the dog to become itchy.
**Steroid mediators, e.g. prostaglandins and leukotriens
**Steroid mediators, e.g. prostaglandins and leukotriens
1. Chemoattractants (attracts mainly [[Neutrophils|neutrophils]] but also [[Eosinophils - WikiBlood|eosinophils]], [[Monocytes|monocytes]] and [[Basophils - WikiBlood|basophils]] and plasma)
1. Chemoattractants (attracts mainly [[Neutrophils|neutrophils]] but also [[Eosinophils - WikiBlood|eosinophils]], [[Monocytes|monocytes]] and [[Basophils|basophils]] and plasma)
2. Vasoactive and inflammatory peptides (e.g. histamine and serotonin) which causes acute contraction of smooth muscle fibres
2. Vasoactive and inflammatory peptides (e.g. histamine and serotonin) which causes acute contraction of smooth muscle fibres