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Text replace - 'Immunoglobulins - WikiBlood' to 'Immunoglobulins'
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**Most polymorphic regions of class II are in the alpha 1 and beta 1 domains
 
**Most polymorphic regions of class II are in the alpha 1 and beta 1 domains
 
*Most polymorphisms are point mutations
 
*Most polymorphisms are point mutations
* There are millions of variations in [[Immunoglobulins - WikiBlood|antibodies]] and TCR
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* There are millions of variations in [[Immunoglobulins|antibodies]] and TCR
 
** However, with MHC there is very limited variation between molecules
 
** However, with MHC there is very limited variation between molecules
 
*Allelic variation within the MHC molecule occurs at the peptide binding site and on the top or sides of the binding cleft
 
*Allelic variation within the MHC molecule occurs at the peptide binding site and on the top or sides of the binding cleft