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Created page with '{{review}} <p>''Shortened to IgG''</p> thumb|150px|right|'''IgG''' thumb|right|150px|IgG - B. Catchpole, RVC 2008 <p>IgG is the major antib…'
{{review}}
<p>''Shortened to IgG''</p>
[[Image:LH IgG.png|thumb|150px|right|'''IgG''']]
[[Image:IgG.jpg|thumb|right|150px|IgG - B. Catchpole, RVC 2008]]
<p>IgG is the major antibody in blood plasma and constitutes at least 80% of all antibody in the body. It is the smallest immunoglobulin so it can readily leave the blood plasma and enter tissues.</p>
==Structure==
<p>IgG is Y-shaped with three constant regions and a heavy chain subunit type γ. There are several different IgG subclasses depending on the species coded for by the IGHG gene.
*Ruminants have three subclasses
**G1-G3
**IgG1 is the major antibody in ruminant mucosal secretions and colostrum
* Dogs, rodents (and cats?) have four subclasses
**Dogs: G1-G4
**Rodents: G1-G3 (G2a, G2b)
*Pigs have five subclasses
**G1-G4 (G2a, G2b)
*Horses have six subclasses
**G1-G6</p>
==Production==
<p>IgG is produced by plasma cells in the spleen, bone marrow and lymph nodes.</p>
==Function==
<p>
*Some IgG subclasses can activate complement via the classical pathway
*Some subclasses act as targets for macrophages, eosinophils and [[Neutrophils|neutrophils]]
** It is therefore the major antibody in tissue fluids and lymph
*IgG specifically binds to antigens on bacteria
**Causing agglutination and opsonisation</p>
<br>
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<center><b><sup>[[Immunoglobulins|Immunoglobulins]]: [[Immunoglobulin A|Immunoglobulin A]], [[Immunoglobulin D|Immunoglobulin D]], [[Immunoglobulin E - WikiBlood|Immunoglobulin E]], [[Immunoglobulin G - WikiBlood|Immunoglobulin G]] & [[Immunoglobulin M - WikiBlood|Immunoglobulin M]]</sup></b></center>
<p>''Shortened to IgG''</p>
[[Image:LH IgG.png|thumb|150px|right|'''IgG''']]
[[Image:IgG.jpg|thumb|right|150px|IgG - B. Catchpole, RVC 2008]]
<p>IgG is the major antibody in blood plasma and constitutes at least 80% of all antibody in the body. It is the smallest immunoglobulin so it can readily leave the blood plasma and enter tissues.</p>
==Structure==
<p>IgG is Y-shaped with three constant regions and a heavy chain subunit type γ. There are several different IgG subclasses depending on the species coded for by the IGHG gene.
*Ruminants have three subclasses
**G1-G3
**IgG1 is the major antibody in ruminant mucosal secretions and colostrum
* Dogs, rodents (and cats?) have four subclasses
**Dogs: G1-G4
**Rodents: G1-G3 (G2a, G2b)
*Pigs have five subclasses
**G1-G4 (G2a, G2b)
*Horses have six subclasses
**G1-G6</p>
==Production==
<p>IgG is produced by plasma cells in the spleen, bone marrow and lymph nodes.</p>
==Function==
<p>
*Some IgG subclasses can activate complement via the classical pathway
*Some subclasses act as targets for macrophages, eosinophils and [[Neutrophils|neutrophils]]
** It is therefore the major antibody in tissue fluids and lymph
*IgG specifically binds to antigens on bacteria
**Causing agglutination and opsonisation</p>
<br>
----
<center><b><sup>[[Immunoglobulins|Immunoglobulins]]: [[Immunoglobulin A|Immunoglobulin A]], [[Immunoglobulin D|Immunoglobulin D]], [[Immunoglobulin E - WikiBlood|Immunoglobulin E]], [[Immunoglobulin G - WikiBlood|Immunoglobulin G]] & [[Immunoglobulin M - WikiBlood|Immunoglobulin M]]</sup></b></center>