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==Description==
 
==Description==
'''Lymphocytic cholangitis''' is a slowly progressive chronic disease characterised by infiltration of the portal areas of the liver with inflammatory cells, mostly [[Lymphocytes|lymphocytes]] and [[B cell differentiation - WikiBlood#Plasma cells|plasma cells]].  Bile duct hypertrophy and [[Liver Fibrosis|fibrosis]] are present.  However, lymphocytic cholangitis does not progress to biliary [[Cirrhosis|cirrhosis]].  An immune-mediated aetiology has been postulated but this has not been substantiated to date.  It is rarely associated with [[Pancreatitis - WikiClinical|pancreatitis]], compared to [[Neutrophilic Cholangitis]]
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'''Lymphocytic cholangitis''' is a slowly progressive chronic disease characterised by infiltration of the portal areas of the liver with inflammatory cells, mostly [[Lymphocytes|lymphocytes]] and [[B cell differentiation - WikiBlood#Plasma cells|plasma cells]].  Bile duct hypertrophy and [[Liver Fibrosis|fibrosis]] are present.  However, lymphocytic cholangitis does not progress to biliary [[Cirrhosis|cirrhosis]].  An immune-mediated aetiology has been postulated but this has not been substantiated to date.  It is rarely associated with [[Pancreatitis - WikiClinical|pancreatitis]], compared to [[Cholangitis, Neutrophilic]]
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**[[Icterus|jaundice]]
 
**[[Icterus|jaundice]]
 
**lymphadenomegaly
 
**lymphadenomegaly
*Severe illness and pyrexia is less likely compared to [[Neutrophilic Cholangitis]].   
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*Severe illness and pyrexia is less likely compared to [[Cholangitis, Neutrophilic]].   
 
*Some cats in the UK are polyphagic and are frequently presented with ascites and/or jaundice.
 
*Some cats in the UK are polyphagic and are frequently presented with ascites and/or jaundice.
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===Laboratory Tests===
 
===Laboratory Tests===
 
====Haematology====
 
====Haematology====
*[[Changes in Inflammatory Cells Circulating in Blood - Pathology#Neutrophilia|Neutrophilia]] is less common than with [[Neutrophilic Cholangitis]]
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*[[Changes in Inflammatory Cells Circulating in Blood - Pathology#Neutrophilia|Neutrophilia]] is less common than with [[Cholangitis, Neutrophilic]]
    
====Biochemistry====
 
====Biochemistry====
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===Histopathology===
 
===Histopathology===
Liver biopsy is important to rule out Feline Infectious Peritonitis.  It is vital to obtain a haemostasis profile prior to biopsy due to risk of prolonged coagulation with liver disease.  It is unnecessary to obtain a bile sample unless the presentation is acute, in which case [[Neutrophilic Cholangitis]] needs to be ruled out.
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Liver biopsy is important to rule out Feline Infectious Peritonitis.  It is vital to obtain a haemostasis profile prior to biopsy due to risk of prolonged coagulation with liver disease.  It is unnecessary to obtain a bile sample unless the presentation is acute, in which case [[Cholangitis, Neutrophilic]] needs to be ruled out.
     
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