Changes

*Widespread on farms - hyperendemic

*Carried as commensals in intestines of cattle, sheep, dogs, wild birds and especially chickens

*Farm animals regularly exposed via faecal-oral route; maternal antibody protects while active immunity develops

*Animals with little exposure are very susceptible, e.g. humans, pets

*Most chicken carcasses contaminated, leading to food poisoning and enterocolitis in people from uncooked meat

*Colonisation, attachment and invasion of colonic enterocytes; toxin production

*Necrosis of colonic absorptive epithelial cells, erosion of mucosa, crypt abscesses, inflammatory infiltrate of [[Neutrophils|neutrophils]] into mucosa causes colitis

 

*Enteritis and diarrhoea in susceptible dogs; treatment with enrofloxacin

It is widespread on farms and is hyperendemic. It can be carried as commensals in the intestines of cattle, sheep, dogs, wild birds and especially chickens.

Farm animals are regularly exposed via the faecal-oral route. Maternal antibody protects the animal while the active immunity develops. Animals with little exposure are very susceptible, e.g. humans and pets.

Most chicken carcasses are contaminated, leading to food poisoning and enterocolitis in people from uncooked meat.

 

Pathogenesis of ''C.jejuni'' involves the colonisation, attachment and invasion of colonic enterocytes and toxin production.

[[Category:Enteritis, Bacterial|Enteritis]] and diarrhoea in susceptible dogs; treatment with enrofloxacin

*Causes abortion in ewes

*Causes abortion in ewes

*Usually asymptomatic infections in chickens and turkeys, but occasional outbreaks of avian hepatitis occur with decreased egg production, loss of condition, haemorrhage and necrosis of liver; phase contrast microscopy demonstrates curved rods in bile; in-feed dihydrostreptomycin sulphate in outbreak

*Usually asymptomatic infections in chickens and turkeys, but occasional outbreaks of avian hepatitis occur with decreased egg production, loss of condition, haemorrhage and necrosis of liver; phase contrast microscopy demonstrates curved rods in bile; in-feed dihydrostreptomycin sulphate in outbreak