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The disease in rabbits and rodents is usually characterised by an unkempt coat, depression and fatal diarrhoea. The disease in foals is an acute septicaemia hepatitis and foals between one and six weeks of age are affected. Clinical signs include depression, loss of suckle reflex, severe icterus, neurological signs, pyrexia and diarrhoea. Foals may be found dead with no preceding clinical signs.
The disease in rabbits and rodents is usually characterised by an unkempt coat, depression and fatal diarrhoea. The disease in foals is an acute septicaemia hepatitis and foals between one and six weeks of age are affected. Clinical signs include depression, loss of suckle reflex, severe icterus, neurological signs, pyrexia and diarrhoea. Foals may be found dead with no preceding clinical signs.
==Diagnosis==
Definitive diagnosis relies on observation of intracellular bacteria at the periphery of liver lesions or bacterial culture. Giemsa stain is used to visualise the bacteria.
==Pathology==
==Pathology==
Grossly, hepatomegaly is present with multifocal white-grey areas of necrosis. The hepatic lymph nodes are often hyperplastic. On cut section the liver displays loss of normal architecture.
Grossly, hepatomegaly is present with multifocal white-grey areas of necrosis. The hepatic lymph nodes are often hyperplastic. On cut section the liver displays loss of normal architecture.
==Treatment==
High dose sodium penicillin and trimethoprim sulpadiazine have been used successfully to treat foals with Tyzzer's disease. Other supportive treatment may include aggressive fluid therapy, parenteral nutrition and control of seizure activity using alpha-2 receptor agonist.
==Prognosis==
The prognosis for foals with Tyzzer's disease is poor.
==Prevention==
No vaccines are available for prevention of Tyzzer's disease. Good hygiene is therefore essential for decreasing the risk of clinical disease.