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==Clinical signs==
==Clinical signs==
The disease in rabbits and rodents is usually characterised by an unkempt coat, depression and fatal diarrhoea. In foals, the disease is an acute septicaemia hepatitis and animals aged between one and six weeks of age are affected. Clinical signs include depression, loss of suckle reflex, severe icterus, neurological signs, pyrexia and diarrhoea. Foals may be found dead with no preceding clinical signs. The course of the disease from the onset of clinical signs to death is usually around 48 hours.
The disease in rabbits and rodents is usually characterised by an unkempt coat, depression and fatal diarrhoea. In foals, the disease is an acute septicaemia hepatitis and animals aged between one and six weeks of age are affected. Clinical signs include depression, loss of suckle reflex, severe icterus, neurological signs, pyrexia and diarrhoea. Foals may be found dead without known preexisting clinical signs. The course of the disease from the onset of clinical signs to death is usually around 48 hours.
==Diagnosis==
==Diagnosis==
Tyzzer's disease should be considered in foals in the above age group with clinical signs indicating hepatic disease and laboratory evidence of hepatic involvement. Definitive diagnosis relies on observation of intracellular bacteria at the periphery of liver lesions or bacterial culture. Giemsa stain is used to visualise the bacteria.
Tyzzer's disease should be considered in foals in the above age group with clinical signs indicating hepatic disease and laboratory evidence of hepatic involvement. Ultrasound of affected animals may show a grossly enlarged liver with rounded edges. Definitive diagnosis relies on observation of intracellular bacteria at the periphery of liver lesions or bacterial culture. Giemsa stain is used to visualise the bacteria.
Laboratory diagnostic tests are of little value in small mammals as death is usually rapid. In foals, clinicopathologic abnormalities often include metabolic acidosis, hypoglycaemia, haemoconcentration and increased hepatic enzymes.
Laboratory diagnostic tests are of little value in small mammals as death is usually rapid. In foals, clinicopathologic abnormalities often include metabolic acidosis, hypoglycaemia, haemoconcentration and increased hepatic enzymes.