Changes

 

[[Lungs Inflammatory - Pathology#Granulomatous pneumonia|granulomatous inflammation]] and tubercle formation.

 

 

The mycobacterium reside within macrophages in the lungs where they multiply and result in characteristic [[Lungs Inflammatory - Pathology#Granulomatous pneumonia|granulomatous inflammation]] The regional lymph nodes and also affected

Microscopically:

Microscopically:

phagocytosed by alveolar macrophages

In the respiratory form the mycobacteria are inhaled, gaining entry to the respiratory system. The organisms are phagocytosed by alveolar macrophages where they multiple and result in a characteristic

......... ultimately, caseous necrosis develops and the nodule ruptures, releasing the organism and infection spreads. The cell mediated immune system produces cytotoxic T-lymphocytes which attack and destroy infected cells, leading to a type IV hypesensitivity reaction.

:- the organism may grow in the phagocytes as intracellular parasites

::- produces a nodule of parasitised swollen macrophages known as a tuburculous nodule or a tubercle granuloma

::- ultimately, macrophages are killed and infection spreads

:- the organism may be broken down and some antigens taken up by the immune system

cell mediated immune system produces cytotoxic T-lymphocytes which attack and destroy infected cells, leading to a type IV hypesensitivity reaction.

[[Category:Cattle]][[Category:To_Do_- lizzyk]]

[[Category:Cattle]][[Category:To_Do_- lizzyk]]

[[Category:Respiratory_Bacterial_Infections]]

[[Category:Respiratory_Bacterial_Infections]]

[[Category:zoonoses]]

[[Category:zoonoses]]