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In contrast, in animals affected by secondary photosensitisation the classic skin lesions are accompanied by the signs of liver disease listed above. Serum biochemistry often reveals increased liver enzymes (ALP, GGT, SDH and ALT) but bilirubin and bile acid concentrations are usually normal. Ultrasonography may be useful in evaluating the hepatic structure and identifying pathological changes indicative of secondary disase. Definitive diagnosis may be obtained by liver biopsy.
In contrast, in animals affected by secondary photosensitisation the classic skin lesions are accompanied by the signs of liver disease listed above. Serum biochemistry often reveals increased liver enzymes (ALP, GGT, SDH and ALT) but bilirubin and bile acid concentrations are usually normal. Ultrasonography may be useful in evaluating the hepatic structure and identifying pathological changes indicative of secondary disase. Definitive diagnosis may be obtained by liver biopsy.
==Treatment==
==Treatment==
==Prognosis==
==Prognosis==
In general the prognosis is favourable for primary photosensitisation and poor for secondary photosensitisation due to hepatic involvement. Cutaneous lesions usually resolve within 48 hours but occasionally may persist for up to six months.
In general the prognosis is favourable for primary photosensitisation and poor for secondary photosensitisation due to hepatic involvement. Cutaneous lesions usually resolve within 48 hours but occasionally may persist for up to six months.
==Prevention==
Animals should not be grazed on pasture known to contain photodynamic agents. Contaminated hay or grain should also be avoided. In the case of farm livestock, less valuable or older animals may be used to 'pre-graze' affected pastures before other animals are introduced.